Dissolution Enhancement of Ibuprofen Solid Dispersion Prepared with Vinyl Polymers by Fusion Method

dissolution rate enhancement of irbesartan using solid dispersion with pegs

dissolution enhancement of glybenclamide by solid dispersion technique

Dissolution enhancement of valsartan using natural polymers by solid dispersion technique

Solid dispersions have been widely used to enhance the solubility of poorly water soluble drugs. In this study, solid dispersions of valsartan (VAL) with natural polymers such as hupu gum (HG), guar gum (GG) and xanthan gum (XG) were prepared by kneading technique in the weight ratios of 1:1,1:2,1:3 and1:4.The prepared solid dispersions were investigated by X-ray diffraction, infrared spectrosc...

Enhancement of Dissolution Rate of Efavirenz by Solid Dispersion Technique

Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, soli...

Investigation of Solid Dispersion Technique in Improvement of Physicochemical Characteristics of Ibuprofen Powder

     Ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), eudragit RS PO, eudragit RL PO and hydroxypropylmethylcellulose (HPMC) as carriers to improve physicochemical characteristics of ibuprofen. The prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissoluti...